membranous nephropathy with mpo-anca-associated crescentic gn
نویسندگان
چکیده
introduction antineutrophil cytoplasmic antibodies (anca)-associated glomerulonephritis (gn) is characterized by necrotizing and crescentic gn with paucity of immunoglobulin (ig) and complement deposition, which is also known as pauci-immune crescentic gn. membranous nephropathy (mn) is characterized by the formation of subepithelial immune deposit with resultant changes in glomerular basement membrane (gbm), most notably spike formation. case presentation a 48-year-old man presented with marked proteinuria, hypoalbuminemia, and renal dysfunction with positive results for myeloperoxidase (mpo) and anca. renal biopsy revealed crescents and thick gbm with subepithelial spikes along with igg deposition on immunofluorescent staining. the condition was diagnosed as mn with mpo-anca-associated crescentic gn. he was treated with intravenous methylprednisolone and cyclophosphamide. after one-month follow-up, antibody level and renal function did not improve. conclusions coexistence of mn with mpo-anca crescentic gn is very rare and should be managed aggressively.
منابع مشابه
Membranous Nephropathy With MPO-ANCA-Associated Crescentic GN
INTRODUCTION Antineutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (GN) is characterized by necrotizing and crescentic GN with paucity of immunoglobulin (Ig) and complement deposition, which is also known as pauci-immune crescentic GN. Membranous nephropathy (MN) is characterized by the formation of subepithelial immune deposit with resultant changes in glomerular basement ...
متن کاملMPO-ANCA crescentic glomerulonephritis complicated by membranous nephropathy: MPO demonstrated in epimembranous deposits
An elderly woman presented with haematuria and proteinuria accompanied by elevated serum myeloperoxidase (MPO)-specific anti-neutrophil cytoplasmic antibodies (MPO-ANCA). A renal biopsy revealed mild mesangial proliferation with fibrocellular crescent formation and a membranous glomerular lesion. Immunofluorescence microscopy using FITC-labelled rabbit anti-human MPO antibodies revealed granula...
متن کاملMPO-C-ANCA-associated necrotising and crescentic glomerulonephritis
The patterns of ANCA staining usually relate closely to antibodies against myeloperoxidase and proteinase-3. C-ANCA is mainly antibodies to proteinase-3 and P-ANCA is antibodies to myeloperoxidase. C-ANCA with antibodies to MPO with clinical sequelae is unusual.
متن کاملCoexistent Membranous Nephropathy with Doubly ANCA-Associated Crescentic Glomerulonephritis: A Case Report and Review of Literature
Introduction: Membranous nephropathy (MN) is the most common causes of the nephrotic syndrome in nondiabetic, Caucasian adults. Pauci-immune necrotizing and crescentic glomerulonephritis (PNCGN) typically present with rapidly progressive glomerulonephritis. Coexistent MN and PNCGN is a rare occurrence. We report a case of both MPOand PR3-ANCA associated NCGN with MN that presented as rapidly pr...
متن کاملMembranous glomerulonephritis with ANCA-associated necrotizing and crescentic glomerulonephritis.
BACKGROUND AND OBJECTIVES Only rare cases of concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been reported. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The authors report the clinical and pathologic findings in 14 patients with MGN and ANCA-associated NCGN. RESULTS The cohort...
متن کاملCC Chemokine Ligand 18 in ANCA-Associated Crescentic GN.
ANCA-associated vasculitis is the most frequent cause of crescentic GN. To define new molecular and/or cellular biomarkers of this disease in the kidney, we performed microarray analyses of renal biopsy samples from patients with ANCA-associated crescentic GN. Expression profiles were correlated with clinical data in a prospective study of patients with renal ANCA disease. CC chemokine ligand 1...
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عنوان ژورنال:
nephro-urology monthlyجلد ۶، شماره ۶، صفحات ۰-۰
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